RESEARCH OF 2-THIOURACIL DERIVATIVES BY X-RAY METHOD

Abstract

2-Propargylthio-6-methyl-5-ethyl-4(3H)-pyrimidinone has been synthesized by alkylation of S-sodium salt of 6-methyl-5-ethyl-2-thiouracil with propargyl bromide. It has been found by X-ray method that S-derivatives of 2-thiouracil are in the tautomeric form with the proton at the nitrogen atom N³_. The substitute at the sulfur atom is within the plane of pyrimidine ring at the angle 59–84°. The 2-alkylthio-4(3H)-pyrimidinones molecules are combined in dimers with formation of two intermolecular hydrogen bonds.