SYNTHESIS OF 3-ALLYLTHIO-5-ОXO-1,2,4-TRIAZINE-6-CARBOXYLIC AND 2-ALLYL-5-АMINO-1,2,4-TRIAZINE-6-CARBOXYLIC ACIDS

Abstract

The mixture of 3-mercapto-5-oxo-1,2,4-triazine-6-carboxylic and 3-oxo-5-amino-1,2,4-triazine-6-carboxylic acids have been obtained by cyclization of alloxan-5-thiosemicarbazone under NaOH. Interaction of the mixture of compounds 3 and 6 with allyl bromide in the NaOH–H2O–DMSO medium proceeds to give 2-allyl-5-amino-3-oxo-1,2,4-triazine-6-carboxylic acid. By one-pot synthesis the 3-allylthio-5-oxo-1,2,4-triazine-6-carboxylic acid has been synthesized.